Recent Publications about Uterine Fibroids

Jayes F, Liu B, Aviles S, et al. Evidence of collagen and biomechanical heterogeneity in uterine fibroids. PLoS One. 2019 Apr 29;14(4):e0215646. doi: 10.1371/journal.pone.0215646. eCollection 2019

Singh B, Trueheart I, Sims H, et al. An open-label, dose-escalation study to assess safety and tolerability of collagenase Clostridium histolyticum (EN3835) in subjects with uterine leiomyoma. Reproductive Science 2021. https://doi.org/10.1007/s43032-021-00573-8

Leppert PC, Al-Hendy A, Baird D, et al. Summary of the Proceedings of the Basic Science of Uterine Fibroids Meeting, February 28, 2020. 2020. F&S Science, doi: https://doi.org/10.1016/j.xfss.2020.11.001.2020. 2021, 2:1, 88-100.

Islam MS, Afrin S, Singh B, et al. Extracellular matrix and Hippo signaling as target of antifibrotic compounds for the treatment of uterine fibroids. Clinical and Translational Medicine. 2021:11.e475 https://doi.org/10.1002/ctm2.475

Schlaff WD, Ackerman RT, Al-Hendy A, et al. Elagolix for Heavy Menstrual Bleeding in Women with Uterine Fibroids. N Engl J Med. 2020 Jan 23;382(4):328-340. doi: 10.1056/NEJMoa1904351. PMID: 31971678.

Stewart EA, Missmer SA, Rocca WA. Moving Beyond Reflexive and Prophylactic Gynecologic Surgery. Mayo Clinic Proceedings.2021 February 1; 98:2 291-94. https://doi.org/10.1016/j.mayocp.2020.05.012

George JW, Fan H, Johnson B, et al. Integrated Epigenome, Exome, and Transcriptome Analyses Reveal Molecular Subtypes and Homeotic Transformation in Uterine Fibroids. Cell Rep. 2019 Dec 17;29(12):4069-4085.e6. doi: 10.1016/j.celrep.2019.11.077. PMID: 31851934; PMCID: PMC695671

Purdy MP, Ducharme M, Haak AJ, et al. YAP/TAZ are Activated by Mechanical and Hormonal Stimuli in Myometrium and Exhibit Increased Baseline Activation in Uterine Fibroids. Reprod Sci. 2020 Apr;27(4):1074-1085. doi: 10.1007/s43032-019-00106-4. Epub 2020 Feb 13. PMID: 32056132.

Ciebiera M, Ali M, Prince L, et al. The Evolving Role of Natural Compounds in the Medical Treatment of Uterine Fibroids. J Clin Med. 2020 May 14;9(5):1479. doi: 10.3390/jcm9051479. PMID: 32423112; PMCID: PMC7290481.

Ulin M, Ali M, Chaudhry ZT, et al. Uterine fibroids in menopause and perimenopause. Menopause. 2020 Feb;27(2):238-242. doi: 10.1097/GME.0000000000001438. PMID: 31834160; PMCID: PMC6994343.

Stewart EA, Lytle BL, Thomas L, et al. The Comparing Options for Management: PAtient-centered REsults for Uterine Fibroids (COMPARE-UF) registry: rationale and design. Am J Obstet Gynecol. 2018 Jul;219(1):95.e1-95.e10. doi: 10.1016/j.ajog.2018.05.004. Epub 2018 May 8. PMID: 29750955.

Afrin S, Islam MS, Patzkowsky K, et al. Simvastatin ameliorates altered mechanotransduction in uterine leiomyoma cells. Am J Obstet Gynecol. 2020 Nov;223(5):733.e1-733.e14. doi: 10.1016/j.ajog.2020.05.012. Epub 2020 May 15. PMID: 32417359; PMCID: PMC7609626.

Tinelli A, Catherino WH, Gargiulo AR, et al. Uterine Fibroids: From Molecular Oncology to Reproduction. Biomed Res Int. 2018 Sep 3;2018:6284875. doi: 10.1155/2018/6284875. PMID: 30250848; PMCID: PMC6140000.